DoxyPEP Treatment

Dosage schedule

200 mg (two capsules), taken within 72 hours of potential exposure, ideally within 24 hours.

Length of Treatment

Single dose of two capsules taken once. No daily dosing.

Side effects

Nausea, stomach upset, and increased sun sensitivity. Rarely, rashes or swallowing difficulties occur.

Further Actions

Continue routine STI testing and other prevention methods as advised.

Locations

London, Birmingham

Fees

£30

Journey Overview

#1 Medication Questionnaire & Initial Assessment

As part of the initial process, patients must complete our medications questionnaire. This serves as an initial clinical assessment and allows us to review the timing of the exposure, relevant medical history, current medications, and any known allergies.

STI testing via Drop & Go may be offered at this stage but is not mandatory. The information provided helps determine whether DoxyPEP may be appropriate and whether any further review is required.

#2 Clinician Review & Consultation (If Appropriate)

If further clarification or assessment is required, a remote consultation by telephone will be arranged. During this review, the clinician will:

• Confirm whether DoxyPEP is safe and suitable for you
• Discuss the exposure in more detail
• Assess whether HIV post-exposure prophylaxis (PEPSE) or other prevention options are needed

Not all patients will require a telephone consultation, and many can proceed based on questionnaire review alone.

#3 Dispense Medications

Once approved, DoxyPEP is supplied as a single 200 mg dose of doxycycline, taken as two capsules together. The medication may be:

• Collected from the clinic, or
• Sent by post, depending on timing and preference

Clear instructions will be provided on how to take the medication safely.

#4 Further Care

Further care includes STI testing via Drop & Go, either if this was not completed earlier or as part of routine follow-up after the appropriate window period.

Patients should arrange a review if any symptoms develop, such as discharge, sores, or pain, as DoxyPEP does not provide complete protection and does not treat established infections.

If DoxyPEP is required repeatedly, our Specialists may discuss long-term prevention strategies, including regular screening and HIV prevention options, to support ongoing sexual health.

Patient Feedback

    
 
 
       Posted on Google  
    C  
 
 
 
 Trustindex verifies that the original source of the review is Google. I've been trying to get my coil replaced since May on the NHS, but they couldn't do it as my threads have been cut too short. Waiting lists for NHS gynae appointment are insane (~1 year) so after some deliberating I decided to go private. I chose Clarewell Clinics as they had great reviews and also compared to other clinics, were a lot more reasonably priced.

I booked an ultrasound guided coil removal in hopes that Dr. Elena would be able to do it without needing to go down a more invasive route. Thankfully, she did it with ease and also replaced it with a Mirena coil (on the NHS they had told me my uterus was too small so had to go with Kyleena).

It was such a more pleasant experience than when I did it on the NHS. Dr. Elena and Yemi kept me comfortable and eased my anxiety the whole way through the process. The pain relief options were also better- air and gas was a lifesaver! I could still feel the pain but it was milder and so much more bareable than the insertion I had 5 years ago. It was over quickly and I was sent away with a heat pack to ease the cramping afterwards.

Thank you so much Dr Elena, Yemi and also Ryaan for being a friendly face in the reception.

I would thoroughly recommend Clarewell Clinics :)
  
 
      Posted on Google  
    K S 
 
 
 
 Trustindex verifies that the original source of the review is Google. I had a mirena replacement with Elena, supported by Ryan.
I have previously had bad experiences, but the approach here and the pain management meant if I had to come back next week for another one, I’d do it.
I arrived feeling sick and shaking but Ryan put me at ease, Elena did a fantastic and quick job and the gas and air made a huge difference, I barely felt anything.  The whole team were friendly and welcoming and I wouldn’t hesitate to recommend them.  I had an injection and she didn’t wait for pain to come to manage it, it was managed upfront.  I’m so incredibly grateful, thank you.  Ryan and Elena are a fantastic team
  
 
      Posted on Google  
    P R 
 
 
 
 Trustindex verifies that the original source of the review is Google. Mr Aaron Williams saw us while we were visiting London from the US and he treated us well, with compassion and professionalism. Seeing him helped put us at ease for the rest of our trip, which ended up being great.
  
 
      Posted on Google  
    E R 
 
 
 
 Trustindex verifies that the original source of the review is Google. Incredible care and treatment. Can't thank Dr Jayadeva and his team enough who put me at great ease and looked after me. Wonderful clinic will be recommending.
  
 
      Posted on Google  
    A L 
 
 
 
 Trustindex verifies that the original source of the review is Google. I had a copper coil removal yesterday with Dr Praveen Jayadeva. If you are at all nervous about an iud fitting or removal, I couldn't recommend this clinic enough. I had a very painful experience at a different clinic that made me really scared about the removal procedure. They really take the time to talk you through what's going to happen and what type of pain relief options you have. They were so friendly and comforting (both the doctor and the amazing assistant) and procedure was so quick. They even offer you tea and biscuits afterwards. Really fantastic and professional clinic!
  
 
      Posted on Google  
    B G 
 
 
 
 Trustindex verifies that the original source of the review is Google. I had a coil done here. It was an amazing experience, really worth the money paid. The doctor took the time to go through the process and all the options in detail. I felt prepared and well cared for. I had numbing gel and spray and also gas and air. The actual coil fitting was less then 5 minutes. I felt a little discomfort, but the gas and air managed this very well. The team were all very supportive and caring.
My coil lasts for 5 years, I'm very happy with my experience. Could not recommend enough.
  
 
      Posted on Google  
    D  
 
 
 
 Trustindex verifies that the original source of the review is Google. Dr. Malu was able to help me fully understand and put into context my concerns surrounding HPV, which at times can feel like a confusing subject. His ability to listen and understand my concerns with empathy and without judgement was very helpful. I am grateful for the expertise and care given by Dr. Malu and the staff at his clinic. The team provides a very professional and comfortable experience.
  
 
      Posted on Google  
    A R 
 
 
 
 Trustindex verifies that the original source of the review is Google. Fantastic and caring team from booking process, reception, appointment and billing. Went for a coil removal. They had ultrasound and gas for pain management (when I checked it seemed they were the only clinic that offered this!!). 100% recommend. Especially if you’re getting a coil, want to make sure you do it with a top professional team. I inserted it elsewhere and it was a barbaric procedure for me, insanely painful and just awful. So save yourself unnecessary trauma/pain
  
 
      Posted on Google  
    A  
 
 
 
 Trustindex verifies that the original source of the review is Google. I had such a great experience at Clarewell Clinic. I was extremely nervous about the pain before my copper IUD fitting, but Dr Praveen Jayadeva explained everything clearly throughout the appointment and made me feel completely comfortable. I was given pain relief and the fitting was honestly so much easier than I expected — I barely felt any pain at all. Yasmin was also incredibly lovely and reassuring throughout. I’m genuinely so happy I chose Clarewell and would definitely recommend them. 10/10.

Eligibility

Best For

Potential exposure to chlamydia or syphilis within 72 hours

Pregnancy/Breastfeeding

Generally avoided during pregnancy and breastfeeding. Consult clinician for safe alternative options.

Menstruation

Safe to use during menstruation.

Prior/Repeat Use

Not intended for frequent or routine use. Repeat requests require a clinical review to address antibiotic resistance.

Do NOT use if

Allergic to tetracyclines, significant renal or hepatic disease

Avoid/Discuss if

Symptomatic, or past 72 hours since exposure

FAQs

Show All Answers

What is DoxyPEP Treatment?

DoxyPEP (Doxycycline Post-Exposure Prophylaxis) is a single preventive dose of doxycycline (200 mg) taken after sex to reduce the risk of certain bacterial STIs, mainly chlamydia and syphilis. It is not reliable for preventing gonorrhoea.

It must be taken within 72 hours of exposure, ideally within 24 hours. A clinical review is required before prescribing.

How effective is DoxyPEP?

DoxyPEP can reduce the risk of:

• Chlamydia and syphilis by around 70–80% in studied groups
• Gonorrhoea: effectiveness is limited due to antibiotic resistance

It does not protect against HIV, viral STIs, or pregnancy.

How and when should I take DoxyPEP?

• Take two capsules together (200 mg total)
• Take with food and a full glass of water
• Stay upright for at least 30 minutes
• Take as soon as possible after sex (within 72 hours maximum)

Avoid strong sun exposure for a few days.

Is DoxyPEP safe? Are there side effects?

Most people tolerate a single dose well. Possible side effects include:

• Mild nausea or indigestion
• Throat or stomach irritation
• Increased sensitivity to sunlight

Seek medical advice if you develop a severe rash, difficulty swallowing, or persistent pain.

Who should not take DoxyPEP?

DoxyPEP is not recommended during pregnancy or breastfeeding. If this applies to you, alternative sexual health support and testing will be discussed instead.

Does DoxyPEP replace condoms or STI testing?

No. DoxyPEP is an extra layer of protection, not a replacement for:

• Condoms
• Regular STI testing
• HIV prevention strategies

Follow-up testing is still essential.

Do I need follow-up testing after DoxyPEP?

Yes. A full STI screen is recommended 2–6 weeks after exposure, even if you feel well. If symptoms appear at any point, book a review immediately.

What if I develop symptoms after taking DoxyPEP?

If symptoms such as discharge, pain, sores, or irritation appear:

• Contact our Specialists for assessment
• Avoid sexual contact
• Arrange a full STI screen

DoxyPEP does not treat active infections and may mask symptoms.

Should my partner also take DoxyPEP?

DoxyPEP is an individual preventive treatment. Your partner would need their own clinical assessment to determine whether it is appropriate for them.

If a test later comes back positive, partner notification and treatment are recommended.

Do I need to tell my partners I’ve taken DoxyPEP?

This is your choice, but open communication about sexual health is encouraged. DoxyPEP only protects you, not your partner, and does not remove the need for testing.

Can I use DoxyPEP regularly or as a home treatment?

No. DoxyPEP is:

• Prescription-only
• Not intended for frequent or routine use
• Overuse may contribute to antibiotic resistance

It should only be taken after a clinical review.

Does menopause affect DoxyPEP effectiveness?

Menopause does not reduce how DoxyPEP works. However, vaginal dryness or thinning may increase infection risk, so lubrication and regular testing remain important. There are no known interactions with HRT.

Does DoxyPEP protect against HIV?

No. DoxyPEP does not protect against HIV. If HIV exposure is a concern, PEPSE may be needed and should be assessed urgently.

Next Steps

In Clinic

Same day test results +/- medications available for most infections.

With Consultation

Without Consultation

Online

Start, continue or finish your care online.

Online Consultation

Online Medications

Not sure what you need? Contact us here.

Page last reviewed by Aaron Williams 17 October 2023 for general guidance only. It is not intended to replace the advice of your clinician.